SMAP: A Segmental Maximum A Posteriori Approach to Array-CGH Copy Number Profiling

نویسندگان

  • Robin Andersson
  • Jan Komorowski
چکیده

2 Observations The glioblastoma multiforme data is stored in a data.frame which needs to be converted to a SMAPObservations object prior to analysis. The required arguments for the SMAPObservations constructor function are: value A numeric vector of intensity ratios for each clone on the array chromosome A character vector of chromosomes annotated to the clones on the array startPosition A numeric vector of start positions (bp) of the sequences corresponding to the clones on the array

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A segmental maximum a posteriori approach to genome-wide copy number profiling

MOTIVATION Copy number profiling methods aim at assigning DNA copy numbers to chromosomal regions using measurements from microarray-based comparative genomic hybridizations. Among the proposed methods to this end, Hidden Markov Model (HMM)-based approaches seem promising since DNA copy number transitions are naturally captured in the model. Current discrete-index HMM-based approaches do not, h...

متن کامل

P-243: Prenatal Diagnosis Using Array CGH: Case Presentation

Background: Karyotype analysis has been the standard and reliable procedure for prenatal cytogenetic diagnosis since the 1970s. However, the major limitation remains requirement for cell culture, resulting in a delay of as much as 14 days to get the test results.CGH array technology has proven to be useful in detecting causative genomic imbalances or genetic mutations in as many as 15% of child...

متن کامل

Accurate detection of aneuploidies in array CGH and gene expression microarray data

MOTIVATION Chromosomal copy number changes (aneuploidies) are common in cell populations that undergo multiple cell divisions including yeast strains, cell lines and tumor cells. Identification of aneuploidies is critical in evolutionary studies, where changes in copy number serve an adaptive purpose, as well as in cancer studies, where amplifications and deletions of chromosomal regions have b...

متن کامل

Induced G1 phase arrest of fast-dividing cells improves the quality of genomic profiles generated by array-CGH.

Genome-wide profiling of copy number alterations by array-based high resolution comparative genomic hybridization (array-CGH) is an important method to ensure the genomic integrity of cells in diverse conditions. We observed that the analysis of genomic profiles, in particular of fast-dividing murine leukemia cell lines, is challenging due to characteristic patterns oscillating around the array...

متن کامل

P-112: PGS-Array-CGH Technique: New Technical Approach to Promotion ART Outcome

Background Chromosomal abnormalities are common in embryos from assisted reproductive technology, ranging from 60% abnormal embryos in women

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2016